The Practice Of Medicinal Chemistry

The Practice of Medicinal Chemistry PDF
Author: Camille Georges Wermuth
Publisher: Elsevier
ISBN: 012417213X
Size: 43.51 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 902
View: 2075

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Book Description: The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com

The Practice Of Medicinal Chemistry

The Practice of Medicinal Chemistry PDF
Author: C. G. Wermuth
Publisher: Elsevier
ISBN: 0127444815
Size: 41.33 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : en
Pages : 768
View: 690

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Book Description: Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists with little or no background in medicinal chemistry. These chemists must acquire a good knowledge of medicinal chemistry during their first years in the pharmaceutical/drug discovery industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. The book reviews practical aspects of Medicinal Chemistry, emphasising the daily problems met by the medicinal chemist when dealing with lead discovery/identification methodologies, with structure-activity relationship studies aimed to scale up potency and target selectivity, and when optimising pharmacokinetic and pharmaceutical properties by means of ultimate chemical modifications. This is the second edition of The Practice of Medicinal Chemistry, the first edition being published in February 1996. The new edition is thoroughly revised, with around 30% new material, and refocussed to reflect the recent developments in genomics, proteomics, high throughput screening of compounds and drug solubilisation. An effort has been made to remove the overlap that exists in the previous edition and four new chapters have been introduced. * Written by experts in the field * The first edition of The Practice of Medicinal Chemistry, published in 1996, was nicknamed 'The Bible' by medicinal chemists. * The only available book dealing with the practical aspects of medicinal chemistry, from conception of the molecules through to the production of drugs * An essential practical handbook for the medicinal chemist, working in the pharmaceutical industry, with little or no background in medicinal chemistry-a complete guide to the drug discovery process.

Annual Reports In Medicinal Chemistry

Annual Reports in Medicinal Chemistry PDF
Author:
Publisher: Academic Press
ISBN: 9780080583532
Size: 41.68 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 317
View: 1692

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Book Description: Annual Reports in Medicinal Chemistry

Bioisosteres In Medicinal Chemistry

Bioisosteres in Medicinal Chemistry PDF
Author: Nathan Brown
Publisher: John Wiley & Sons
ISBN: 3527654321
Size: 45.57 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 256
View: 2793

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Book Description: Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

New Developments In Medicinal Chemistry

New Developments in Medicinal Chemistry PDF
Author: Carlton Anthony Taft
Publisher: Bentham Science Publishers
ISBN: 1608051277
Size: 70.57 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : en
Pages : 162
View: 7620

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Book Description: "This book is recommended for readers who are interested in or work with current theoretical and experimental research in medicinal chemistry, with an emphasis on computer aided-drug design and organic synthesis for therapeutic purposes. This book encompas"

The Science And Applications Of Synthetic And Systems Biology

The Science and Applications of Synthetic and Systems Biology PDF
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309219396
Size: 18.71 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 570
View: 4136

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Book Description: Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

The Handbook Of Medicinal Chemistry

The Handbook of Medicinal Chemistry PDF
Author: Andrew Davis
Publisher: Royal Society of Chemistry
ISBN: 1849736251
Size: 66.88 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 753
View: 3949

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Book Description: Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry has been revised and brought up to date to cover the past, present and future of the entire drug development process.

Green Techniques For Organic Synthesis And Medicinal Chemistry

Green Techniques for Organic Synthesis and Medicinal Chemistry PDF
Author: Wei Zhang
Publisher: John Wiley & Sons
ISBN: 1118308654
Size: 60.67 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 768
View: 681

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Book Description: An updated overview of the rapidly developing field of green engineering techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.

The Chemical Gazette Or Journal Of Practical Chemistry In All Its Applications To Pharmacy Arts And Manufactures

The Chemical Gazette  Or  Journal of Practical Chemistry  in All Its Applications to Pharmacy  Arts  and Manufactures PDF
Author:
Publisher:
ISBN:
Size: 62.36 MB
Format: PDF
Category : Chemistry
Languages : en
Pages :
View: 6996

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Book Description: